Next-Generation Sequencing to Guide Clinical Trials
نویسندگان
چکیده
منابع مشابه
Next-Generation Sequencing to Guide Clinical Trials.
Rapidly accruing knowledge of the mutational landscape of malignant neoplasms, the increasing facility of massively parallel genomic sequencing, and the availability of drugs targeting many "driver" molecular abnormalities have spurred the oncologic community to consider how to use these new tools to improve cancer treatment. In order to assure that assignment of patients to a particular target...
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Abstract DNA sequencing is one of the great valuable techniques in molecular biology, which can be used to detect the sequence of nucleotides in a DNA fragment. The high-throughput sequencing known as Next Generation Sequencing (NGS) revolutionized genomic research and molecular biology; therefore, the whole human genome can be sequenced with a low cost in several days. NGS technology is simi...
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Large tumor sequencing studies have demonstrated that human cancers of a given histologic type are often heterogeneous with regard to the mutations that drive their invasion and that the mutations present in individual tumors have major influences on the natural history of the tumor, and its responsiveness to therapy. These findings are having a major impact on the development and evaluation of...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2015
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-14-3215